FLO vs FLP

Brief title: FLO/FLP
Design: Randomized phase III trial in patients with advanced adenocarcinoma of the stomach receiving first-line chemotherapy with fluorouracil, leucovorin and oxaliplatin (FLO) versus fluorouracil, leucovorin and cisplatin (FLP)
No of patients: 180
Status: Completed

Randomized, open, multicentre phase II study comparing FLO with FLP chemotherapy in patients with advanced gastric cancer or adenocarcinoma of the esophagogastric junction without palliative chemotherapy. Primary outcome measure was survival after six months. Secondary outcome measures were toxicities, overall survival and response rate.

LKP:
Prof. Dr. S.E. Al-Batran
Institut für Klinisch-Onkologische Forschung
Krankenhaus Nordwest GmbH
Steinbacher Hohl 2-26
60488 Frankfurt/Main

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FLOT65+

Brief title: FLOT65+
Design: A multicenter, randomised phase II trial on the therapy of advanced gastric cancer or adenocarcinoma of the esophagogastric junction in patients older than 65 years with specific regard of quality of life and pharmacogenetic risk profile 
No of patients: 140
Status: Completed

In the present phase II trial, the response rate, the pharmacogenetic risc profil, the quality of life and the safety and tolerability in patients with advanced gastric or esophagogastric cancer will be evauluated.

LKP:
Prof. Dr. S.E. Al-Batran
Institut für Klinisch-Onkologische Forschung
Krankenhaus Nordwest GmbH
Steinbacher Hohl 2-26
60488 Frankfurt/Main

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FLOT

Brief title: FLOT
Design: Biweekly fluorouracil, leucovirin, oxaliplatin, and docetaxel (FLOT) for patients with metastatic adenocarcinoma of the stomach or esophagogastric junction.
No of patients: 59
Status: Completed

Multicentre, open phase II study with FLOT for patients with metastatic adenocarcinoma of the stomach or esophageal junction. Primary end point was the resonse rate. Secondary end points were toxicities and progression free survival.

LKP:
Prof. Dr. S.E. Al-Batran
Institut für Klinisch-Onkologische Forschung
Krankenhaus Nordwest GmbH
Steinbacher Hohl 2-26
60488 Frankfurt/Main

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